Category Archives: low thiol sulfur

Eureka! methylation and high thiol sulfur: CBS/COMT/NOS/DAO

by Bea Garth, copyright 2018

I have been reading Dr. Ben Lynch’s new book called DIRTY GENES. It  helped me finally put the missing pieces into the puzzle for some of my most plaguing health issues. The study of Methylation, genetic snps and epi-genetics  has finally started to progress to where it  can help many people struggling with underlying health problems. By  figuring out what genetic snps  one has, it becomes easier to learn how to avoid possible pitfalls.

"At the Diner," pen and ink by Bea Garth, copyright 2018
“At the Diner,” pen and ink by Bea Garth, copyright 2018

It appears that in my case, my CBS snp (along with my COMT/ plus NOS/DAO/MTHFR etc. snps) has been causing me no end of trouble by creating too much toxic ammonia in my system. The high thiol sulfur set off severe urinary tract system difficulties when I was a young adult. Plus more recently it has been creating problems with such things as sleep, skin, collagen issues and nerve degeneration.

I have a friend whom I have been helping who is also being similarly helped by this new diet even though  his epi-genetics and symptoms are slightly different. For him his most disturbing symptom has been the development of intestinal microbes he just has not been able to get rid of, which then have caused him great pain in his gut as well as chronic insomnia, brain fog and frequent intense joint pain.

Although he does not cover the CBS genetic snp in his book,  Dr. Lynch’s clear explanation of the methylation process and how the snps inter-relate with each other (and epi-genetics) has enabled me to make much better sense of it all.  As a result, I  have finally put my finger on what has been causing me (and my friend) so much trouble with so many foods.

As it turns out, if the CBS snp becomes stressed, it can make one sensitive to  high thiol sulfur which then turns into toxic ammonia given the body’s inability to methylate it properly. That in combination with a couple of my stressed COMT genes makes a very difficult stew, so to speak.

And yes my epi-genetics have been stressed, I’ll say. Both due to getting severely sick as a small infant (my older brother says from six months to a year) due to  the secret Hanford Radiation experiment in December 1949 called The Green Run (they release between 8000 and 12,000 curies of radioactive iodine as well as other toxic radioactive materials into the atmosphere along the Columbia River). Plus exposure to umpteen toxic materials repairing old houses for my family business for over twenty years. My friend too has suffered from working on old houses, both those of my family as well as others when he was working as a carpenter and painter.

The last few years both my health and that of my friend’s has gradually been going down hill despite my (and our doctors’) best efforts to help both of us. But now finally with this new knowledge about the CBS snp and others such as COMT, DAO, NOS and MTHFR, both he and I are starting to feel so much better it amazes me–simply by going on a low thiol diet! Over time I am hopeful that many of our symptoms will finally resolve by following what we are learning from our snps and supporting our epi-genetics through diet, exercise, meditation and whatever methods we can use to help keep detoxified.

It makes sense that high thiols creating toxic ammonia have been a scourge for me.  I lost the use of half my right kidney when I was 23 years old after all. Despite my doctors (who wanted me to be on antibiotics the rest of my what would have been a very short life), I went  off the antibiotics anyway. I was getting rashes, large welts and ringing ears along with brain fog from almost all of the antibiotics, including sulfa drugs.

My grandmother suggested I might be sensitive to various foods, the worst possibly being citrus fruit. I soon discovered she was right. Eventually, through extensive trial and error, I figured out I am very sensitive to the wheat family and most milk products, although I kept eating yogurt for years. It was suggested I was sensitive to fructose but, as it turns out, that was not correct. Instead I eventually discovered I am very sensitive to high histamine foods, which includes a lot of fruit, and  to any fruit that is over-ripe. In addition I found I am very reactive to any foods that are red or purple. One nice thing that I have discovered almost immediately after going on a low thiol diet is t hat it is now OK for me to eat yellow and green apples. Previously if I ate an apple it helped contribute to  keeping me awake at night.

According to Dr. Andy Cutler (see link at bottom of list below), there is a big connection to needing a low thiol-sulfur diet if one suffers from a  mercury overload from dental amalgams. Certainly in my case I did not do well at all with silver mercury amalgams — they gave me gum-boils as a child and continued to cause ringing in my ears and gave me a metallic taste in my mouth as an adult. No doubt this mercury toxicity underlay  my developing kidney disease when I was 23. Even by age 13, I had developed severe bladder problems when I was on the basketball team. I finally had the amalgams slowly removed when I was almost 40–which helped quite a lot, but did not resolve all of my health issues.  As usual, I continued detoxing using herbs such as dandelion root and much later added in bentonite clay. I eventually got rid of the mercury, however I still continued to have problems particularly as I aged although its true  my work renovating old houses did not help me with my need for detoxification.

Again, for my friend, his health plummeted after he got a mouth full of silver amalgam fillings topped with metal caps. After that, his job continuing to work on old houses (sometimes involving removing toxic materials plus painting) did not help. Although he had his amalgams removed over 10 years ago, he continued to have problems. In his case he has two homozygous CBS genes, so he has been even more easily affected than I have been to  toxins. It is no wonder he started having problems with his prostate and at times found it difficult to walk or even think due to all the excess ammonia. He was able to heal in part through the use of acupuncture, Chinese herbs and diet, but he continued to be very weak. It is only now he is starting to feel  less pain in his gut by changing his diet to low thiol foods. Already he is starting to sleep a little better. Hopefully in time his debilitating brain fog will also lift.

My feeling is that once the CBS gene mutation has been turned on by something like toxic mercury, one has to continue to support it through diet and some method of detoxing, even after the mercury or other toxins  have been removed due to the fact that the ammonia is creating its own havoc, often supported by toxic biofilms.

The truth is, I had skirted around this thiol sensitivity without really knowing what it was. I figured my health issues must be both environmental and genetic (as you will note if you see some of my older posts), but honestly I did not know what exactly was causing it or what to do about it. My reactions to many of the high sulfur foods was not clearly obvious since the symptoms from them were more insidious, in part covered up by my taking various detox herbs since my early twenties (to keep my kidneys and liver detoxed), as well my severe reaction to foods that did not seem to relate to each other like gluten, nuts, citrus and milk not to speak of red and purple foods. Although  I knew I shouldn’t eat a lot of chard for instance in order to avoid the scourge of developing kidney stones, I continued to eat fairly high thiol dark green vegetables. (Ironically, chard is one of the less high thiol sulfur greens.)

Despite all the healing I had already done, I was gradually going under.  Since my mother’s death and my move with my husband up north to Washington, my insomnia and itching got way worse. I went around feeling partly like a zombie. It was hard to figure out, but I finally did just this last year. I realized eventually that eggs and other high sulfur foods such as garlic, onions, broccoli and cabbage were making it nearly impossible for me to sleep. However I was still eating kale and occasionally bok choi. And a host of other high thiol foods I shouldn’t have been eating like buckwheat. I was getting weaker and weaker, not to speak of the embarrassment of having weird hours due to my inability to sleep on any kind of regular schedule.  I also  have had to resort to wearing dresses and skirts rather than wearing pants  due to the severe itching.

What a roller coaster this has been!!

Now on low thiol foods plus of course continuing to eat fairly low histamine foods with no gluten or milk products etc., both my friend and I are starting to sleep better at night plus we are starting to feel more energetic and clear. And yes that was a big discovery for my friend. It was his snps that gave us the clue since he  has a homozygous DAO snp.  It turns out he needs to avoid high histamine foods, the very opposite of what he thought!

We both still  have more ways to go, however it seems clear that our various symptoms  are starting to  lessen as we continue on this healing path. If not, I need to look at some of the other snps that might also be bothering both my friend and me. But all in all, I am very happy my friend and I are finally beginning to get our lives back at last!

Dr. Ben Lynch offers this key advice in his book: it is important for most of us to eat a bit of carbohydrate, protein and fat with each meal in order to support and not stress things out like serotonin and dopamine–especially important for someone like me and my friend who have COMT snps too. Fruit and vegetables also continue to be very important, though my friend and I have to make sure they are low histamine overall, and low thiol sulfur — and for me, not red or purple. Eventually as we heal more, from what I read, we should be able to add in some  medium thiol foods as long as we continue to detox.

And yes I am discovering too we need to be careful regarding supplements since  a lot of them are high thiol, or are thiol inducing such as MSM, epsom salt baths, NAC, milk thistle and turmeric.

In case you want to learn more about CBS and low thiol foods plus COMT, here are  some good links below that you can check out. The last one of which lists foods that are both high and low thiol. It has a discussion by Andy Cutler on how mercury often initiates a reaction to high thiol foods.

OK so here’s the list of links: